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Smiles: CN1CCN(CC2=CC=C(C=C2)C(=O)NC2C=C(NC3=NC(=CS3)C3=CC=CN=C3)C(C)=CC=2)CC1
InChi: InChI=1S/C10H8N4O3S
potent and orally active γ-secretase modulator (GSM)
24 or 72 h) does not induce apoptosis of HCA-7 and LLC cells
(S)-Lisofylline Catalog No.:M22422-C Smiles: CN1CCN(CC2=CC=C(C=C2)C(=O)NC2C=C(NC3=NC(=CS3)C3=CC=CN=C3)C(C)=CC=2)CC1Lisofylline (LSF) is a potent anti inflammatory agent. LSF is a chiral metabolite of pentoxifylline . Pentoxifylline is exclusively reduced to (S) LSF in the cytosol when metabolized by isolated human liver cells . In vitro: Lisofylline preserved cell insulin secretion and inhibited DNA damage of islets in the presence of IL 1 . Simultaneous application of LSF and cytokines to INS 1 cells restored insulin secretion, mitochondrial membrane potential,